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TENUATE at Work

If you eat an excessive amount of fat or calories, the excess is stored as fat by the body, resulting in weight gain. When you eat fat, your body breaks it down into its simplest components so that it can be digested.

Unlike other weight-loss drugs you may have heard about that act in the brain or central nervous system to suppress appetite or to speed up metabolism, TENUATE works in your digestive system to block about one-third of the fat in the food you eat from being digested.

Tenuate is used as a short-term supplement to diet and exercise in the treatment of obesity.

Tenuate usually is taken three times a day, 1 hour before meals (regular tablets), or once a day in midmorning (extended-release tablets).

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  Tenuate Side Effects

What are the possible side effects of tenuate?

If you experience any of the following serious side effects, stop taking tenuate and seek emergency medical attention:

- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or
- abnormal behavior, or confusion.

Other, less serious side effects may be more likely to occur. Continue to take tenuate and talk to your doctor if you experience

- restlessness or tremor,
- nervousness or anxiety,
- headache or dizziness,
- insomnia,
- dry mouth or an unpleasant taste in your mouth,
- diarrhea or constipation, or
- changes in your sex drive.
Tenuate is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect tenuate?

You cannot take tenuate if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.

Changes in insulin and other diabetes drug therapies may be necessary during treatment with tenuate.

Tenuate may reduce the effects of guanethidine (Ismelin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine.

Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of tenuate.

Drugs other than those listed here may also interact with tenuate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
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